In a mouse model of chronic myeloid leukemia, c-Myc downregulation by the Fbw7 ubiquitin ligase plays a pivotal role towards quiescence in Leukemia Initiating Cells (LICs) resistant to Imatinib [40]. The gene discussed is FBXW7; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.