In this context, our data support the notion that 5FU-resistant colon cancer cells enter into quiescence following 5FU treatment and subsequent proteasomal degradation of YAP and Cyclin E as direct substrates of the β-TrCP and Fbw7 ubiquitin ligases, respectively [7, 41]. Here, FBXW7 is linked to malignant colon neoplasm.