In our current study, we examined the mutational status of 17 genes relevant to myeloid malignancies, and found that patients with h-MDS had lower number of concurrent genetic alterations, similar to the report by Nazha et al. However, in contrast to their report, we could not find a negative association of SF3B1 and IDH1/2 mutations with h-MDS. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.