HIV-1 infection also induces genotoxic stresses linked to p53 activation in CD4+ T cells by integration mediated- dsDNA strands break, secretion of type I interferons and expression of HIV-1 accessory proteins Vpr/Vpu, which may be considered as intracellular markers of HIV-1 infection [8–11]. The gene discussed is TP53; the disease is HIV-1 infection.