ESR1 and Hepatic fibrosis: The strongest overlap between the 10-top-output pathways of mixed and individual was observed for APOBEC3G (5/10) and PTPRC/CD45 (5/10) indicating the strongest contribution from those two genes; in contrast, no overlap was found for ESR1. Similarly to the algorithm I-derived results, Hepatic Fibrosis/Hepatic Stellate Cell Activation pathway was as well ranked to position 1 when the algorithm II was applied, where the priority is given to the overlap between the output_mixed and output_individual (Additional file 1: Table S15).