However, for SNPs satisfying p<1 × 10−4 in the combined meta-analysis, four pathways were significantly associated with Barrett's oesophagus and oesophageal adenocarcinoma (appendix p 14): negative regulation of muscle-cell differentiation (GO:0051148); mesenchyme development (GO:0060485); BMPR2 PPI subnetwork (ENSG00000204217); and mesenchymal cell differentiation (GO:0048762). The gene discussed is BMPR2; the disease is Barrett esophagus.