Of note, all seven new genome-wide significant loci from the separate Barrett's oesophagus and oesophageal adenocarcinoma meta-analyses were also identified in the combined meta-analysis except for one locus on chromosome 3q27 near HTR3C and ABCC5 (rs9823696) that was only recorded in the oesophageal adenocarcinoma meta-analysis and, therefore, was specific for this disorder (risk for oesophageal adenocarcinoma: odds ratio [OR] 1·17, 95% CI 1·11–1·24; p=1·64 × 10−8; risk for Barrett's oesophagus: 1·02, 0·97–1·06; p=0·45). This evidence concerns the gene ABCC5 and Barrett esophagus.