The corresponding gene product belongs to the group of ATP-binding cassette membrane proteins that play a part in energy-dependent transport of various endogenous and exogenous substrates and has been implicated in cancer development and progression.33, 34 Furthermore, as with other oesophageal adenocarcinoma genes implicated by genome-wide association studies (eg, FOXF1 and FOXP1),7, 9ABCC5 has a role during embryonal development of the intestine.35 This evidence concerns the gene FOXF1 and esophageal adenocarcinoma.