A number of preclinical and clinical studies have demonstrated that GC administration, at high doses and/or chronic periods (days to weeks), promotes a dysregulation in hepatic glucose metabolism that is directly related to the reduction of the insulin action in the liver, which ultimately means hepatic GC-induced insulin resistance (IR) [6,17,19,24,25,26,27] (Table 1). Here, INS is linked to Insulin resistance.