Interleukin 18 (IL-18), fetuin-A, soluble intercellular adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) are a group of cytokines and adhesion molecules which activate and deregulate endothelial function, and could increase the risk of atherosclerosis [13,14,15,16,17,18,19,20]. The gene discussed is AHSG; the disease is atherosclerosis.