The results of the univariate and multivariable logistic regression analysis and step-wise analysis of serum IL-18, fetuin-A, sICAM-1, and ET-1 levels in SpA patients who were smokers and non-smokers and with and without comorbidities such as IHD, hypertension, and diabetes showed no differences (all p > 0.05). This evidence concerns the gene EDN1 and Hypertension.