Our results demonstrate that the antitumor activity of MPT0G066 was 13.28-fold more potent than the antitumor activity of paclitaxel, and MPT0G066 effectively promotes the apoptotic pathway without the influence of p-gp in multi-drug resistant ovarian cancer cell lines NCI/ADR-RES (Fig. 4). The gene discussed is PGP; the disease is ovarian cancer.