Patients with certain background medical histories (such as Beckwith Wiedemann syndrome, Familial adenomatous polyposis (FAP)) are prone to develop hepatoblastomas, whereas those with underlying glycogen storage diseases, biliary atresia, alpha-1 anti-trypsin deficiency and tyrosinaemia are prone to developing HCC. Here, SERPINA1 is linked to Familial adenomatous polyposis.