LCN2 and acute kidney injury: One single-center RCT from Germany included 231 critically ill patients with KDIGO stage 2 AKI and plasma neutrophil gelatinase-associated lipocalin (NGAL) >150 ng/Ml, and defined early RRT as initiation within 8 h of diagnosis of stage 2 AKI and delayed RRT as initiation within 12 h of stage 3 AKI [37].