Recent clinical trials and basic research demonstrated that CRP could be a proatherogenic factor for atherosclerosis [3], whereas in-vitro experiments reported that CRP preparations had been contaminated by bacterial products or other contaminated preparations [4, 5], and a recent study showed that no proinflammatory cytokines or acute phase proteins were detected after purified CRP from pooled normal human donor plasma was infused into seven healthy adult human volunteers [6]. This evidence concerns the gene CRP and atherosclerosis.