LGALS3 and neoplasm: We then performed histological analysis of the primary tumor 21 and 28 days p.o.i. and found an increased necrotic area (Fig. 2a, p < 0,01) and percentage of proliferative cells (Fig. 2b, p < 0,05) in 4T1 tumors grown in the absence of galectin-3 (Lgals3−/−).