TNF and cancer: Interestingly, accumulating evidence suggests a complex and context-dependent role for the NF-ĸB pathway in cancer, including the ability to maintain cellular senescence.28, 29, 30 PRL-3 was found to activate the NF-ĸB pathway in a TNFα-independent manner by interacting with RAP1,31 but how PRL-3 ablation leads to increased TNFα levels in TNBC cells remains poorly understood and warrants further investigation.