We have recently identified FLICE/caspase-8-associated huge protein (FLASH)/casp8ap2 as a repressor of E-cadherin expression through posttranscriptional control of ZEB1.16 Loss of FLASH specifically decreased ZEB1 protein expression in cancer cells resulting in de-repression of ZEB1-regulated genes involved in maintenance of the epithelial phenotype, such as E-cadherin. The gene discussed is ZEB1; the disease is cancer.