Previously, we reported that loss of FLASH significantly upregulated E-cadherin (CDH1) gene expression in the cervical cancer line HeLa 229.16 To determine whether FLASH is a conserved regulator of E-cadherin in cancer cells, we silenced CASP8AP2/FLASH gene expression by siRNA duplexes in four distinct cell lines generated from diverse tissues. Here, CASP8AP2 is linked to cancer.