CASP8AP2 and cancer: An essential element of EMT progression is induction of chemotherapy resistance.12, 26, 27 In pancreatic cells, ZEB1 expression level correlates with chemotherapy resistance to gemcitabine, 5-fluorouracil and cisplatin.12 In this study, we uncovered that loss of FLASH or loss of ZEB1 antagonized gemcitabine resistance in PANC-1 cancer cells.