Depletion of FLASH in HeLa 229 (cervical cancer), MDA-MB-231 (triple-negative breast cancer), PANC-1 (pancreatic cancer) and PC-3M (prostate cancer) resulted in high expression of E-cadherin at the protein (Figure 1a, Mock vs FLASH KD) and mRNA level (Figure 1b, Mock vs FLASH KD). The gene discussed is CASP8AP2; the disease is familial pancreatic carcinoma.