Except for the RCAN1-1L isoform, which promotes angiogenesis, the overexpression of RCAN1-4, RCAN2 and RCAN3 in human umbilical vein endothelial cells has been reported to inhibit cell proliferation and migration.39, 40, 41 A correlation between RCAN2 and bone turnover,42 obesity43 and response to anabolic steroid administration44 has also been reported in organs in which its expression is abundant; however, to date, the correlation between RCAN2 and cancer has not been studied. Here, RCAN1 is linked to cancer.