RNF8 and cancer: FOXM1 has been shown to enhance cancer cell proliferation and protect cells from genotoxic agents by promoting DNA damage repair.5, 8, 13 Considering our finding that RNF168 and RNF8 target FOXM1 for degradation in response to epirubicin, we next investigated whether FOXM1 is a target for the anti-proliferative function of RNF168 and RNF8.