FOXM1 and cancer: Recent research also indicates that deregulated FOXM1 overexpression confers genotoxic and other cancer chemotherapeutic agent resistance.2, 3, 4, 5, 6, 7 There is already ample evidence, indicating that FOXM1 acts as a mediator of DDR and a modulator of genotoxic agent sensitivity, through regulating the expression of genes, including BRIP1, NBS1, EXO1, XRCC1, RAD51 and RFC4, involved in DDR.4, 5, 8, 9, 10 Despite the importance of FOXM1 in DNA-damaging agent response, the exact mechanisms by which FOXM1 is regulated by genotoxic agents remain a crucial unresolved issue.