Histological analysis of livers from p62f/f, p62-/-, p62hep+/+and p62hep-/- mice fed DDC for 8 weeks (Fig 1A, panel 2), in contrast to animals fed a normal diet (Fig 1A, panel 1), revealed the occurrence of characteristic features of DDC-induced liver injury, such as porphyria (brown pigment deposition), bridging fibrosis, inflammation and ballooning of hepatocytes (compare panels 1 and 2). The gene discussed is SQSTM1; the disease is porphyria.