SERPINB5 and lip and oral cavity carcinoma: However, among alcohol consumers, people with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 G/C polymorphism had a 4.42-fold (95% CI: 1.80–10.81; P = 0.001) and a 3.01-fold (95% CI: 1.22–7.38; P = 0.01) increased risk to develop oral cancer compared to those with C/C homozygotes.