SERPINB5 and lip and oral cavity carcinoma: In this present study, we found that participants with G/G homozygotes (AOR: 2.07; 95% CI: 1.13–3.77; P = 0.01) or with G/C heterozygotes (AOR: 2.01; 95% CI: 1.09–3.70; P = 0.02) of Maspin rs2289520 G/C polymorphisms were significantly associated with increased oral cancer risk compared to those with C/C homozygotes after adjusting confound factors.