Also, G/G homozygotes of Maspin rs1455555 polymorphism and T/T homozygotes of Maspin rs2289519 polymorphism had a 2.01-fold (95% CI: 1.00–4.05; P = 0.04) and a 2.20-fold (95% CI: 1.02–4.73; P = 0.04) risk to progress oral cancer among alcohol consumers, after adjusting confounders. This evidence concerns the gene SERPINB5 and lip and oral cavity carcinoma.