In our study, among alcohol consumers but not for non- alcohol consumers, people with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 G/C polymorphism had a 4.42-fold (95% CI: 1.80–10.81; P = .001) and a 3.01-fold (95% CI: 1.22–7.38; P = .01) increased risk to develop oral cancer compared with those with C/C homozygotes. Here, SERPINB5 is linked to lip and oral cavity carcinoma.