Non-AIDS mortality was associated with both older age, adjusted HR compared with those aged <60 years 4.35 [95% CI 2.97–6.39], IDU status (3.40 [2.26–5.12]), lower CD4 (2.42 [1.49–3.94]) and prior AIDS diagnosis (1.58 [1.27–1.95]). This evidence concerns the gene CD4 and AIDS.