However, LY294002 only inhibited p-Akt and p-mTOR, and rapamycin only inhibited p-mTOR, indicating that c-Met/PI3K/Akt/mTOR signaling is a key pathway that involved in the roles of HGF in lung cancer, and might be also the main target of curcumin. The gene discussed is AKT1; the disease is lung cancer.