In the vasculature, c-Met activation via HGF plays an important role in regulating tumor angiogenesis.30 Recent studies indicate that PI3k/Akt pathway is involved in HGF-induced lung endothelial cells migration.31 To investigate the role of PI3k/Akt signaling in HGF-mediated angiogenesis, we used SU11274, LY294002, and rapamycin to inhibit c-Met/PI3k/Akt signaling respectively. Here, HGF is linked to neoplasm.