Ponzo et al have reported that c-Met is expressed in endothelial cells and that HGF can stimulate endothelial cell growth, invasion and motility.40 Also, inhibition of c-Met activity impairs the survival, invasion, and tubulogenesis of HUVECs in vitro and reduces neovascularization and microvessel formation in tumor models.41,42 In accordance with this evidence, our results showed that curcumin at the low concentration could effectively inhibit endothelial cell migration and capillary structure formation in HGF stimulation models in vitro. This evidence concerns the gene HGF and neoplasm.