REN and Hyperglycemia: In order for DN to occur several factors should coincide, among which are the effect of genetic susceptibility, hyperglycemia, activation of the polyol pathways, activation of the renin-angiotensin system, activation of the protein kinase C pathway, increase in the advanced glycation end products (AGEs), glomerular hyperfiltration, and the production of reactive oxygen species (ROS) [3].