HRH2 and erectile dysfunction: Diabetes mellitus is a risk factor for erectile dysfunction [36], and long-term use of histamine H2 receptor antagonists (e.g., Cimetidine) in gastroduodenal ulcer treatment leads to reduced libido. E. speciosa has been cited for its ethnopharmacological application in diabetes management [14] and other workers [10, 37] have reported the cytoprotective and antisecretory effects of E. speciosa extract in peptic ulcer management.