The HOMA-IR index has been validated as an acceptable proxy measure of insulin resistance in both normal and diabetic people with a good correlation (correlation coefficient: 0.73–0.88) between estimates of IR derived from HOMA and from the euglycemic clamp, and with a good correlation (correlation coefficient: 0.62–0.90) between estimates of β-cell function using HOMA and estimates using continuous infusion glucose model assessment, hyperinsulinemic clamps, the acute insulin response from the intravenous glucose tolerance test [16–18]. This evidence concerns the gene INS and Insulin resistance.