TSLP and allergic disease: The thymic stromal lymphopoietin-Basophil response/pathway has been shown to contribute to the pathogenesis of EoE based on rodent and human studies.22, 23 Milk sphingolipids have shown to activate peripheral iNKT cells in EoE in children to produce Th2-type cytokine response.24 In addition, iNKT cell-associated markers were found to be upregulated in patients with EoE and correlated with the expression of inflammatory mediators associated with allergy.