The CD3+CD8+ T cells had higher potential than CD3+CD4+ T cells to secrete TNF-α and IFN-γ in the EoE-New/Active vs EoE-Remission, suggesting that response to treatment leads to downregulation of TNF-α and IFN-γ production to levels as seen in controls. The gene discussed is TNF; the disease is eosinophilic esophagitis.