According to Ingenuity Pathway Analysis (IPA), this panel of analytes found in EoE-New/Active patients centered around TNF-α and fit into known pathways that are involved in various functions including: hematologic system development and function (P=2.18 × 10−16), immune cell trafficking (P=1.77 × 10−17), inflammatory response (P=2.18 × 10−16), cellular movement (P=1.77 × 10−17), cell-to-cell signaling (P=2.18 × 10−16) and tissue development (P=4.57 × 10−16). Here, TNF is linked to eosinophilic esophagitis.