TSHR and nodular goiter: The results showed that iodine content in follicular lumen of nodular goiter was less than that in control group; moreover, the content of iodine in follicular lumen was found to be negatively correlated with TSHR (rs = −0.857; P < 0.01), TTF-1 (rs = −0.805; P < 0.01), and PAX8 (rs = −0.652; P < 0.05) expression in nodular goiter.