CYFIP1 and early-onset autosomal dominant Alzheimer disease: This particular increase in CYFIP1 expression in severe Alzheimer’s disease hippocampus, but not in severe Alzheimer’s disease superior temporal gyrus, may represent a late wave of further neurodegeneration in the disease, or alternatively a compensatory mechanism contributing to the survival of some hippocampal neurons in the disease (Westet al., 1994).