We performed western blot analysis with hippocampal protein from patients with mild Alzheimer’s disease and did not observe a downregulation of CYFIP1 expression (t= −1.28,P= 0.22;Supplementary Fig. 5AandSupplementary Data), contrary to the results for CYFIP2 expression (Fig. 1D). Here, CYFIP1 is linked to early-onset autosomal dominant Alzheimer disease.