Translation of the mRNA encoding β-site APP cleaving enzyme 1 (BACE1) is increased by amyloid-β42action on cultured neurons (Sadleiret al., 2014;Mamadaet al., 2015) and in an Alzheimer’s disease mouse model (Caccamoet al., 2015). This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.