We tested also whether the increased αCaMKII protein expression correlates with altered tau phosphorylation at serine-214 (S214), a site that is phosphorylated by CaMKII, and one of the key sites that are hyperphosphorylated in Alzheimer’s disease (Leeet al., 2001). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.