MAPT and early-onset autosomal dominant Alzheimer disease: Interestingly, FMRP also prevents local translation of mRNA encoding α-isoform of calcium/calmodulin-dependent kinase II (αCaMKII, encoded byCAMK2A) (Darnellet al., 2011), a kinase implicated in tau hyperphosphorylation and Alzheimer’s disease (Ghosh and Giese, 2015).