Unexpectedly, we found a downregulation of CYFIP1 expression by ∼60% in 12-month-old Tg2576 mice (t= −5.49,P< 0.01;Supplementary Fig. 5G), instead of an upregulation of CYFIP1 expression observed in post-mortem, severe Alzheimer’s disease hippocampus (Supplementary Fig. 5D). Here, CYFIP1 is linked to early-onset autosomal dominant Alzheimer disease.