BCL2 and B-cell chronic lymphocytic leukemia: Our data are compatible with the rs539846-A allele conferring increased CLL risk through reduced RELA-mediated expression of the pro-apoptotic BCL2 family gene, BMF. Furthermore, epigenetic and chromosome conformation capture data are consistent with rs539846 localizing within a chromatin contact domain, overlapping a B cell super-enhancer (Hnisz et al., 2013).