GWASs of chronic lymphocytic leukemia (CLL) have identified 31 risk loci, with the signal annotating B cell lymphoma 2 (BCL2)-modifying factor (BMF) at 15q15.1 being highly robust (Berndt et al., 2013, Berndt et al., 2016, Crowther-Swanepoel et al., 2010, Di Bernardo et al., 2008, Slager et al., 2011, Slager et al., 2012, Speedy et al., 2014). This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.