BMF and plasma cell myeloma: Indeed, previous studies in the myeloma cell line U266 have reported that siRNA-mediated knockdown of BMF is associated with a decrease in apoptosis following treatment with arsenic trioxide (Morales et al., 2008), whereas mice lacking Bmf develop a B cell lymphadenopathy caused by a resistance of B cells to apoptosis (Labi et al., 2008).