PPA2 and cardiomyopathy: Four candidate genes were identified with compounding missense mutations and with an association to cardiomyopathy and/or mitochondrial function: KCNJ12 (MIM: 602323), TTN (MIM: 188840), AARS2 (MIM: 612035), and PPA2. Of these four genes, variants in all but PPA2 were excluded based on non-segregation with disease (Table S2).