Our data suggest that the RUNX1t1 tumor suppressive function might be related to repression of C/EBPβ DNA binding, reminiscent to its function in the adipogenic clonal expansion phase that requires expression of C/EBPβ but also RUNX1t1 to prevent premature induction of C/EBPα and terminal fat cell differentiation [33]. This evidence concerns the gene RUNX1T1 and neoplasm.