Although it is clear that the Cdh23 753A allele increases susceptibility to NIHL, results from a few studies, including our own, demonstrate that additional loci in the genomes of inbred mice contribute to this susceptibility (Vázquez et al. 2004; White et al. 2009; Li 1992; Harding et al. 2005). Here, CDH23 is linked to noise induced hearing loss.