HNF1B and neoplasm: Compared to HNF1A, HNF1B is the best candidate to bind to this motif because the HNF1B gene itself is also down-regulated in the tumor samples (log ratio = −1.34, p-value = 6.24 × 10−5) and its expression profile is strongly correlated with the predicted targets (Pearson correlation = 0.71, p-value < 2.2 × 10−16), although HFN1A is also strongly correlated with these genes (Pearson correlation = 0.52, p-value = 1.67 × 10−10).