MYH14 and distal myopathy: Laing distal myopathy (LDM) muscle biopsies sometimes show i) changes in muscle fiber size with type I hypotrophy, ii) co-expression of slow and fast myosin, iii) mild necrosis and regeneration iv) while mitochondrial abnormalities are not a common feature of LDM biopsies, the presence of serpiginous cytoplasmic bodies, possibly as sign of secondary sarcomeric disruption, had been described in one family with a substitution to proline [6, 7] In contrast, myosin storage myopathy muscle biopsies consistently show eosinophilic subsarcolemmal aggregates [8].