CDKN2A and non-small cell lung carcinoma: Mutation of D74 to alanine was subsequently detected in a non-small cell lung carcinoma [33], with five somatic, non-synonymous CDKN2A D74 mutations listed in COSMIC for twelve samples: D74Y (COSM12509, larynx, lung, esophagus, gallbladder), D74N (COSM13474, thyroid, esophagus), D74V (COSM13546, larynx, bile duct), D74A (COSM4163712, thyroid) and D74E (COSM13768, skin).