MMP-9 upregulation in three tumor models, the K14 HPV16 skin cancer, the RIP1 TAg2 insulinoma and DU145 prostate tumor resulted in an increase in tumor growth and angiogenesis by activating the gene expression of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule 1 (ICAM-1) [35–37]. This evidence concerns the gene VEGFA and skin cancer.