CCND1 and acute lymphoblastic leukemia: Differently, although Everolimus (1.5 μM) induced G0/G1 cell cycle arrest based on reduced PCNA expression, higher doses (16 μM) increased cyclin D1 expression, no evidence of an accumulation of cells in G0/G1 while increasing apoptosis in pre-B acute lymphoblastic leukemia cells [31].