In addition, a significant NME1-induced enrichment for members of the CDC42 signaling cascade was identified, using Fisher’s exact test (p<0.014),including ARPC5L, CDC42, CDC42EP2, FNBP1L, HLA-DOA, HLA-F, HLA-G, ITGB1, JUN, MYL7, MYL10, MYL12A and RASA1, all of which were regulated by NME1, and linked to metastasis and outcome of patients with melanoma and breast carcinoma[10]. This evidence concerns the gene HLA-DOA and melanoma.