In this systematic review with meta-analysis, although we failed to identify whether the elevated NME1 expression was associated with a poor or well prognosis in patients with digestive system neoplasms, our results indicated that NME1 expression might be related with the clinicopathologic factors of digestive system cancers, including tumor differentiation, N status, and Dukes’ stage. This evidence concerns the gene NME1 and digestive system cancer.