Fig 7A). However, the relationship between NME1 expression and N status failed to obtain the statistical significance in any tumor type (Fig 7B). It was the same to the association between NME1 expression and TNM stage (Fig 7C). In the colorectal cancer, there were eight cohorts reporting the relationship between the expression of NME1 and Dukes’ stage. Though with heterogeneity (I2 = 69%, Ph = 0.002), the combined OR being 0.43 (95%CI:0.24–0.77, P = 0.004. Fig 7D), indicated that elevated NME1 expression was significantly related to Dukes’ stage A and B. This evidence concerns the gene NME1 and colorectal cancer.