Fig 6A). of 25 cohorts showed that high expression of NME1 was significantly associated with well tumor differentiation. Though with heterogeneity (I2 = 72%, Ph<0.00001), 23 cohorts presented data about NME1 expression and N status, and a combined OR being 0.54 (95%CI:0.36–0.82, P = 0.003. Fig 6B) indicated that the positive relationship between increased NME1 expression and negative N status. A pooling OR without any significance, was produced by 16 cohorts which reported the association between NME1 expression and TNM stage (OR = 0.78, 95%CI:0.44–1.36, P = 0.38. Fig 6C). This evidence concerns the gene NME1 and neoplasm.