Nonetheless, the combination of monospecific anti-CD33 with anti-CD123 TMs as well as the single dual-specific anti-CD123-CD33 TM were able to efficiently redirect UniCAR modified T cells of healthy donors against all tested AML cell lines in an effector-to-target ratio of 1:5 and significantly reduce blast numbers (Supplementary Figure 1b). This evidence concerns the gene CD33 and acute myeloid leukemia.