INS and type 2 diabetes mellitus: However, changes in fasting plasma glucose, fasting insulin, blood pressure, total cholesterol, low density lipoprotein cholesterol (LDL-C), and HDL-C were similar across dietary treatments [33].Together, these findings suggest that increasing the protein content of a reduced-energy diet, without a concurrent severe restriction on carbohydrate intake, does not affect the ability of a reduced energy diet to prevent the development of T2DM, compared with a standard low-fat diet approach.