EZH2 and neoplasm: EZH2 is a bona fide oncogene and acts as a dual function transcription regulator (not only repressor but also activator) [47] by converging on the methyltransferase-activity silencing tumor suppressor genes, which are implicated in neoplastic development and the transactivation property-activating genes involved in the late-stage process of cancer [48,49].