TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive: Thus, the greater ROS and TGF-β1 production in CML or pentosidine treated A549 or Calu-6 cells partially explained that these AGEs enhanced oxidative, inflammatory and angiogenic stress in those cells, which might in turn favor the development of microvascular permeability and metastatic actions in lung cancer.