However, we found that CML or pentosidine promoted invasion and migration, increased ROS and inflammatory cytokines production, up-regulated protein expression of RAGE, p47phox, ICAM-1, fibronectin and MMP-2, as well as activated NF-κB and MAPK pathways in A549 and Calu-6 cells. Here, MMP2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.