As shown in Table 1 and Figure 1, CML or pentosidine treatments at test concentrations did not affect proliferation, and protein expression of Bcl-2, Bax, caspase-3 or caspase-8 in A549 cells and Calu-6 cells (p > 0.05). The gene discussed is BAX; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.