However, we found that CML or pentosidine at 1 μmol/L increased p38 phosphorylation in A549 cells, and both AGEs at 2 μmol/L up-regulated NF-κB p65 expression in A549 and Calu-6 cells; but CML at 4 μmol/L raised RAGE expression in two NSCLC cell lines. This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.