Since CML and pentosidine markedly activated RAGE, NF-κB and MAPK pathways in test NSCLC cells, it was reasonable to observe the over-production of ROS, TGF-β1, TNF-α and IL-6 in those NSCLC cells. The gene discussed is TGFB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.