CD8A and neoplasm: In the initial anti-tumor response after stimulation with α-GalCer and dendritic cells (DCs), iNKT cells immediately produce large amounts of IFN-γ, which acts on DCs, NK cells, and neutrophils in the innate immune system to eliminate major histocompatibility complex (MHC) negative tumor target cells and, at the same time, also on CD8 cytotoxic T cells and CD4 Th1 cells to kill MHC positive tumor cells, resulting in tumor eradication [8].