hERG1 was absent in either normal (see black arrow in Figure 2A.5, Figure 2A.6 upper panel, Figure 2B.3 and Figure 2B.4 upper panel) or inflamed (esophagitis) esophageal tissue in both models (Supplementary Figure S2), while it is up-regulated in BE lesions arising in both types of models (Figure 2A.5, Figure 2B.3, Figure 2B.4 lower panel and Figure 2C.1 left panel) (mean score = 130.0 ± 28.7 in the surgical model and mean score = 113.0 ± 37 in the chemical model) as well as in the dysplasia observed in the surgical model (mean score = 270.0) (Figure 2C.1 right panel). The gene discussed is KCNH2; the disease is esophagitis.