Overall, data reported in the present paper indicate that hERG1 identifies patients at higher risk to progress towards EA, and open the possibility of developing a new protocol for the surveillance of BE patients by the in vivo direct detection of hERG1-positive and hERG1-negative BE patients, using the scFv-hERG1-Alexa488. The gene discussed is KCNH2; the disease is Barrett esophagus.