Moving down this line, we designed the present study aimed at: (i) confirming hERG1 expression in a larger cohort of BE patients using an antibody which binds to a different, extracellular, epitope of the hERG1 protein; (ii) determining the expression of hERG1 during BE progression to ED and EA; (iii) testing the possibility of considering hERG1 as a progression marker in BE to be further exploited for BE surveillance screenings. This evidence concerns the gene KCNH2 and Barrett esophagus.