On the plasma membrane ADAM10 can act in shedding the ectodomains of several different membrane-bound substrates which include the precursor forms of growth factors, cytokines, growth- and cytokine-receptors, and various adhesion molecules (reviewed in [22, 23, 29, 30]); therefore, its dysregulation has been reported to have a role in cancer progression and invasion [31–35]. Here, ADAM10 is linked to cancer.