ADAM10 and neoplasm: In the present study, the analysis of the immature ADAM10 on the patient tumor sections was not possible, since in our hands the currently available anti-ADAM10 pro-domain reagent did not work in immunohistochemistry; therefore it is yet to be assessed whether, in addition to an increased expression, the immature ADAM10 is also expressed on the surface of the tumoral cells in patient tissue.