To examine the effect of exogenous IL-33 solely on leukemia-reactive CD8+ T cells, splenic CD8+ T cells purified from either PBS- or IL-33-treated C1498.SIY bearing mice were stimulated with naïve WT DCs pulsed with SIY peptides for detection of IFN-γ production by ELISPOT. The gene discussed is IFNG; the disease is leukemia.