Functional assays showed that transfection with the CXCR4 plasmids in miR-126 overexpressing HCT116 cells significantly ameliorated the miR-126-induced suppression of colon cancer cell migration, invasion and proliferation, respectively (Figures 4B, 4C, 4D). The gene discussed is CXCR4; the disease is malignant colon neoplasm.