We found that higher levels of CXCR4, RhoA, RhoGEF, PI3K, and ROCK correlated positively with TNM stage (p < 0.05) and lymph node metastasis (p < 0.05) but not with age, gender, tumor size or tumor differentiation (Table 1). Here, CXCR4 is linked to metastatic malignant neoplasm in the lymph nodes.