If CXCR4 indeed is a functional target of miR-126 in colon cancer cells, reintroduction of CXCR4 into miR-126 overexpressing HCT116 cells and inhibition of CXCR4 in miR-126-silenced SW480 cells should antagonize the effects of miR-126 on its target genes. The gene discussed is CXCR4; the disease is malignant colon neoplasm.