Other missense mutant SW48/TP53 (TP53) cells, which heterozygously carry p53-R273H knocked in by using a CRISPR/Cas9 genome editing system [28], however, showed responses to doxorubicin similar to those of its parental SW48 colon cancer line (wt p53) (Figure 1A right-panel). This evidence concerns the gene TP53 and malignant colon neoplasm.