Indeed, it has been shown that miR-125-5p induces tumorigenesis in myeloid cells through the repression of IRF4 mRNA [20] and, above all, that the expression of a IRF4 derivative without miR-125-5p binding sites rescues miR-125-5p induced myeloid leukemia [20]. The gene discussed is IRF4; the disease is myeloid leukemia.