However, uPAR is endowed with proteolysis-independent activities; in fact, it binds vitronectin (VN), a component abundant in tumor-associated ECM, interacts with various integrins, regulating their activity, mediates uPA-dependent cell migration and is required for chemotaxis induced by fMet-Leu-Phe (fMLF), a potent leukocyte chemoattractant [8]. Here, VTN is linked to neoplasm.