In summary, we found EHF overexpression in PTCs and demonstrated that EHF promotes thyroid cancer cell growth and invasiveness through transcriptionally regulating HER2 and HER3. Altogether, our data define the oncogenic roles of EHF in thyroid tumorigenesis and suggest that EHF have potential therapeutic value for the treatment of thyroid cancer. The gene discussed is EHF; the disease is thyroid gland disorder.