ESR1 and metastatic malignant neoplasm in the lymph nodes: The A allele in rs2297441 also had a higher frequency in lymph node metastasis, ER and PR positive cases (P = 0.035, 0.041 and 0.042), but had a lower frequency in P53 and C-erbB2 positive cases (P = 0.001 and 0.015).